Synthetic Access to Fluorocyclopropylidenes

Renāte Melngaile, Melita Videja, Jānis Kūka, Artis Kinēns, Dzintars Zacs, Jānis Veliks

SYNTHETIC PROCEDURES AND COMPOUND CHARACTERIZATION .................. S - 4 2.1. Synthesis of starting materials ................................ ................................ ...................... S - 4 2.2. Synthesis of fluorocyclopropylidenes 8a - q ................................ ................................ ... S - 6 2.3. Synthesis of fluorocyclopropylidenes 10a - j ................................ ................................ S - 17 2.4. Epoxidation/ring expansion of cyclopropylidenes: method A ................................ .... S - 24 2.5. Epoxi dation/ring expansion of cyclopropylidenes: method B ................................ .... S - 26 2.6. Hydrogenation of cyclopropylidenes ................................ ................................ .......... S - 29 2.7. Synthesis of ibuprofen analogue 20 ................................ ................................ ............ S - 32 2.8. COX Inhibition assay ................................ ................................ ................................ .. S - 37 2.9. DFT calculations ................................ ................................ ................................ ......... S - 39

Date
30.03.2023.
Keywords
Synthetic Access to Fluorocyclopropylidenes
Hyperlink
https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.3c00579