Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library

Jekaterina Boļšakova, Raitis Bobrovs, Larisa Varacheva, Anastasija Rudnickiha, Iveta Kaņepe, Emilio Parisini, Aigars Jirgensons

Synthesis of compounds 4, 8 - 11 ................................ ................................ ................................ . 2 2. Copies of 1 H - NMR and 13 C - NMR spectra for compounds 4, 8 - 11 ................................ .......... 20 3. PfThrRS Protein expression and purification ................................ ................................ ........... 39 4. Determination of PfThrRS inhibitory potency ................................ ................................ ......... 39 5. ITC Studies for compound binding to Human ThrRS ................................ .............................. 41

Date
14.12.2023.
Keywords
Antimicrobial agents,Inhibitors,Ligands,Noncovalent interactions,Parasites
Hyperlink
https://pubs.acs.org/doi/10.1021/acsmedchemlett.3c00403?goto=supporting-info