Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity

Vadims Kovada, Chrislaine Withers-Martinez, Raitis Bobrovs, Helēna Cīrule, Edgars Liepiņš, Solveiga Grinberga, Fiona Hackett, Christine R Collins, Agrita Kreicberga, Maria Belen Jimenez-Diaz, Inigo Angulo-Barturen, Dace Rasiņa, Edgars Sūna, Kristaps Jaudzems, Michael J Blackman, Aigars Jirgensons

Synthesis of building blocks 23a–d, 26a–d, and 38a,b; 1H NMR, 13C NMR spectra of products 7a–k; and HPLC analysis of final products 7a–k (PDF) The PMX receptor (7TBC) and the docked ligands (6a) (PDB) The PMX receptor (7TBC) and the docked ligands (7k) (PDB) Molecular formula strings and the associated biochemical data (CSV)

Date
28.07.2023.
Keywords
Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity
Hyperlink
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00812?goto=supporting-info