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Innovation application: Calcium Phosphate Nanoparticles for the Applications in Medicine

Title Calcium Phosphate Nanoparticles for the Applications in Medicine, Biotechnologies, Cosmetics and Food Supplements
Abstract

Calcium phosphate material has chemical similarity to human bone and teeth therefore it has excellent biocompatibility and is widely applicable in medicine, biotechnologies and cosmetics. The developed technology can be used for the synthesis of calcium phosphate nanoparticles with average diameter of 20-30 nm. The composition of calcium phosphates is controllable and variable.

Keywords calcium phosphate, hydroxyapatite, implant, toothpaste, protein sorbtion, calcium deficit hydroxyapatite, nanoparticles
Authors Jānis Ločs
Līga Bērziņa-Cimdiņa
Department (14400) Vispārīgās ķīmijas tehnoloģijas institūts
Statistical Classification of Economic Activities, NACE 2 Manufacture of chemicals and chemical products
Description of the technology

Modified large scale calcium phosphate (tricalcium phosphate (TCP) and hydroxyapatite (HAp)) synthesis technology permit to vary the parameters of the synthesis, controlling the Ca/P ratio in the synthesized product. Varying the Ca/P ratio in the calcium phosphates allows to obtain the ceramics with variable HAp/TCP ratio in the sintered bioceramics. The variations of HAp/TCP ratio leads to the variations in the dissolution and resorbtion rate of the implant material in the living body. The technology is "clean technology" as the only by product of the synthesis is the water.

 

Fig. 1. Regenerated bone support for dental implants using calcium phosphates.

Positive, biocompatible implantation results in clinical investigations have been achieved for more than 300 patients in maxillofacial surgery. Currently the evaluations of properties for cosmetic and biotechnological applications are under investigation.

Applications The product can be applicable: 1) in medicine: manufacturing of implant materials with variable composition and biodegradation degree; 2) in cosmetics and food supplements: for the manufacturing of functionalised cosmetics with specific tissue protecting, restoring and osteoporosis prevention functions; 3) in biotechnologies: purification and deposition of biotechnological products.
Advantages

Modified large scale calcium phosphate (tricalcium phosphate (TCP) and hydroxyapatite (HAp)) synthesis methods permit to vary several parameters of the synthesis, controlling the Ca/P ratio in the synthesized product and the HAp/TCP ratio in the sintered ceramics. The technology is upscaleable to the industrial scale. Currently in the lab 1 kg/batch is reached.

Technology Readiness Level Technology validated in relevant environment
Partnership offer Development of new products, technology transfer, research.
Publikācijas
ID 2
Contact information email: santa.puskarjova@rtu.lv and ilmars.viksne@rtu.lv; phone number: +371 29373757 un +371 29187403