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Innovation application: Analytical Services Using Nuclear Magnetic Resonance Spectroscopy

Title Analytical Services Using Nuclear Magnetic Resonance Spectroscopy
Abstract

Nuclear magnetic resonance spectroscopy is a technique used in research for determining the content and molecular structure of a sample. Institute of technology of organic chemistry offers acquisition of nuclear magnetic resonance spectra:

  • 1H-, 13C-, 31P-NMR spectra;
  • HH- and CH-correlation spectroscopy;
  • Qualitative and quantitative (with internal standard) analysis of the mixtures.
Keywords nuclear magnetic resonance, NMR, organic chemistry, quality analysis, deuterated solvents, chemical analysis
Authors Māris Turks
Vitālijs Rjabovs
Jevgeņija Lugiņina
Department (14A00) Organiskās ķīmijas tehnoloģijas institūts
Statistical Classification of Economic Activities, NACE 2 Scientific research and development
Other professional, scientific and technical activities
Description of the technology

1D (1H, 13C, 31P) and 2D (gCOSY, gHSQC, gHMBC, NOESY) NMR spectra are acquired on Bruker Avance 300 spectrometer with Z-gradient module in the solution of deuterated solvents: CDCl3, DMSO-d6, D2O. By an additional arrangement, we offer to acquire spectra in CD3CN, CD3OD, THF-d8, C6D6, C6D5CDsolution. Approx. 5-10 mg (for 1H NMR) and 20-50 mg (for 13C and 2D spectra) of the compound are needed. The sample can be heated to 80 °C (depending on the solvent) and cooled to 0 °C. The acquired data are delivered either as fid/ser files, or as graphic files (jpg, pdf).

Fig. 1. Bruker Avance 300 NMR spectrometer.

Applications Determination of the structure, purity, and properties in solution
Advantages

With Z-gradient module, we can acquire 2D spectra in a relatively short time. Depending on the structure and solubility of the compound, acquisition of 1H-, 13C-, gCOSY, gHSQC, and gHMBC spectra takes only 12 to 24 hours.

Technology Readiness Level Actual system proven in operational environment
Partnership offer Service contracts for acquisition of the NMR spectra.
ID 46
Contact information email: santa.puskarjova@rtu.lv and ilmars.viksne@rtu.lv; phone number: +371 29373757 un +371 29187403