The research concerns to the microclimate control system containing thermoelectric converters – Peltier coolers - integration in the clothes prototype. The temperature measurements modelling experiments are planned to optimize microclimate regulatory garment functionality and to verify microclimate temperature regulatory system efficiency. The aim of experiments - to verify, how the cooling system, integrated in the clothes, influences indicators of the human microclimate. Experiments are carried out both at rest state of the human body, and during physical activities for to compare the effectiveness of micro-climate control system with two and four Peltier elements. To verify microclimate regulatory clothes compliance with the general requirements to the garment, it is scheduled to assess the physiologically - hygienic point of wearing by the appropriate operating conditions, during activities by measuring temperature changes in different locations in space between the body and clothes. To optimize microclimate regulatory system efficiency were carried out experiments with 2 and 4 Peltier coolers. The human microclimate temperature modelling experimental results both with 2, and with 4 elements demonstrate the possibility of the system’s operation, the external environmental temperature influence on the measurement results, as well as the negative impact of the thermoregulatory system with thermoelectric converters on the sweat vapour removal efficiency.