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Publikācija: Release of Anticancer Drug Doxorubicin from Biodegradable Polymer Coated Porous Hydroxyapatite Scaffolds

Publication Type Scientific article indexed in SCOPUS or WOS database
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Release of Anticancer Drug Doxorubicin from Biodegradable Polymer Coated Porous Hydroxyapatite Scaffolds
Field of research 2. Engineering and technology
Sub-field of research 2.5 Materials engineering
Authors Juris Pelšs
Dagnija Loča
Līga Bērziņa-Cimdiņa
Jānis Ločs
Vitālijs Lakevičs
Keywords Doxorubicin, Drug Release, Hydroxyapatite (HA), Poly(Lactic Acid), Polycaprolactone (PCL)
Abstract In the current research slow release anticancer drug delivery system was prepared and drug release kinetics in vitro evaluated. Porous hydroxyapatite (HAp) as carrier material and doxorubicin hydrochloride (DOX) as anticancer agent was used. DOX is an anthracycline drug commonly used in cancer chemotherapy. Unfortunately, its therapeutic potential is restricted cardiotoxicity and resistance developed by the tumor cells to the molecule after treatment. To prepare HAp-DOC composites, the porous bioceramic scaffolds were impregnated with doxorubicin in low vacuum conditions. 10% (HAp-10%PLA) and 20% (HAp-20%PLA) poly lactic acid and 20% (HAp-20%PCL) poly(e-caprolactone) solutions in dichloromethane were used to form the polymer coatings on the drug/bioceramic composites. In general there was a burst release observed from all the samples during the first 2 hours followed by a much reduced release profile. In the next 5 days the drug release from all the samples decreased in the following order: 20% PLA (from 56 ng/ml to 3 ng/ml), 20% PCL (from 196 ng/ml to 6 ng/ml), 10% PLA (from 497 ng/ml to 18 ng/ml). HAp-DOX composite without the polymer coating demonstrated the drug release reduction from 230 ng/ml to 13 ng/ml. The cumulative drug release was observed over 19 days.
DOI: 10.4028/www.scientific.net/AMR.284-286.1770
Reference Pelšs, J., Loča, D., Bērziņa-Cimdiņa, L., Ločs, J., Lakevičs, V. Release of Anticancer Drug Doxorubicin from Biodegradable Polymer Coated Porous Hydroxyapatite Scaffolds. Advanced Materials Research: Materials and Design, 2011, Vol.284-286, pp.1770-1773. ISSN 1662-8985. Available from: doi:10.4028/www.scientific.net/AMR.284-286.1770
Additional information Citation count:
ID 10785