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Publikācija: Silica Nanoparticles for Improving Efficiency of Virus-Like Particle Based Hepatitis B Vaccine

Publication Type Full-text conference paper published in other conference proceedings
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Silica Nanoparticles for Improving Efficiency of Virus-Like Particle Based Hepatitis B Vaccine
Field of research 1. Natural sciences
Sub-field of research 1.3 Physical sciences
Authors Marina Romanova
Jurijs Dehtjars
Anna Kačanovska
Dace Skrastiņa
Regīna Renhofa
Pauls Pumpēns
Aloizijs Patmalnieks
Keywords viral capsids, SiO2, nanoparticles, immunomodulation, optical absorbance
Abstract Adherence of hepatitis B virus-like particles (VLP) to silica (SiO2) nanoparticles was explored for immunomodulation purposes. Optical absorbance measurements, transmission electron microscopy and fluorescence microscopy were employed to study the adherence. The results demonstrated that hepatitis B VLP + SiO2 complexes were formed. Preliminary immunological experiments with vaccination of Balb/c mice with the VLP only and VLP + SiO2 complexes were performed. The vaccination with VLP + SiO2 complexes resulted in increase in antibody production in mice blood. The amount of antibodies produced strongly depended on the concentration of SiO2 nanoparticles. The observed results suggest that SiO2 nanoparticles can be considered as a promising material for improving efficiency of VLP-based vaccines against hepatitis B viral disease.
Reference Romanova, M., Dehtjars, J., Kačanovska, A., Skrastiņa, D., Renhofa, R., Pumpēns, P., Patmalnieks, A. Silica Nanoparticles for Improving Efficiency of Virus-Like Particle Based Hepatitis B Vaccine. In: International Conference on Nanotechnologies and Biomedical Engineering (ICNBME-2011): Proceedings, Moldova, Chisinau, 7-8 July, 2011. Chisinau: Technical University of Moldova, 2011, pp.344-346.
ID 11004