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Publikācija: Silicon Based Nanoparticles Usage as Adjuvants for Treatment of Viral Infections

Publication Type Conference paper
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Silicon Based Nanoparticles Usage as Adjuvants for Treatment of Viral Infections
Field of research 1. Natural sciences
Sub-field of research 1.3 Physical sciences
Authors Jurijs Dehtjars
Anna Kačanovska
Aloizijs Patmalnieks
Pauls Pumpēns
Regīna Renhofa
Marina Romanova
Dace Skrastiņa
Keywords viral capsids, silica, nanoparticles, immunology, hepatitis B, optical absorbance
Abstract Immunomodulation is a new kind of viral infection treatment where molecular agents that are injected inside patient organism stimulate immune system to respond effectively to a viral infection. It is important to deliver immune response-modulating (IM) agents exactly to target cells thus reducing their overall concentration in organism of the patient, which could otherwise lead to side effects. It is possible to use nanocarriers (adjuvants) that are able to pack many IM agents for this purpose. Possible use of Si-n, Si-p and SiO2 nanoparticles as adjuvants was studied in this work. Four different types of virus-like particles (VLP) were used as IM agents. The systems Si based nanoparticle – VLP were created. The systems were studied by means of spectrophotometry as well as by electron and fluorescent microscopy. The study showed that Si-n, Si-p and SiO2 nanoparticles can be used as nanocarriers for corresponding VLP. VLP packing properties depend on the surface charge of both VLP and nanoparticle. Vaccination of animals with the SiO2 nanoparticle – Hepatitis B virus VLP system resulted in twelve-time increase in antibody synthesis.
Reference Dehtjars, J., Kačanovska, A., Patmalnieks, A., Pumpēns, P., Renhofa, R., Romanova, M., Skrastiņa, D. Silicon Based Nanoparticles Usage as Adjuvants for Treatment of Viral Infections. In: International Baltic Sea Region Conference "Functional Materials and Nanotechnologies 2010" (FM&NT): Proceedings, Latvia, Riga, 16-19 March, 2010. Riga: Institute of Solid State Physics, University of Latvia, 2010, pp.56-56.
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