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Publikācija: Self-Assembling Capsides – Nanoparticles Complex

Publication Type Conference paper
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Self-Assembling Capsides – Nanoparticles Complex
Field of research 1. Natural sciences
Sub-field of research 1.3 Physical sciences
Authors Jurijs Dehtjars
Anna Kačanovska
Aloizijs Patmalnieks
Pauls Pumpēns
Regīna Renhofa
Marina Romanova
Dace Skrastiņa
Keywords viral capsids, silica, nanoparticles, immunology, hepatitis B, optical absorbance
Abstract Virus-like particles - capsides - are under intensive studies nowadays due to broad perspective for its applications as intracellular drug delivery agents. To ensure the effective treatment, the concentration of capsides in cell vicinity and inside the cell has to be high. One way to increase the local capsides concentration is grouping them all together, for instance, by attaching them to adjuvants - nanoparticles. These nanoparticles serve as „nano-lorry" which would deliver capsides inside the cell and reduce their residual concentration in the intracellular liquid. The present work explores possibility to use silicon dioxide nanoparticles as adjuvant to Hepatitis B capsides to create complexes „capsides - nanoparticles". Spectrophotometric measurements, electron and fluorescent microscopy demonstrated formation of the above complexes. In addition, vaccination of animals with the complexes-based vaccine resulted in twetve-time increase in antibody synthesis.
Reference Dehtjars, J., Kačanovska, A., Patmalnieks, A., Pumpēns, P., Renhofa, R., Romanova, M., Skrastiņa, D. Self-Assembling Capsides – Nanoparticles Complex. In: ScanBalt Forum 2010: Book of Abstracts, Estonia, Tallinn, 22-24 September, 2010. Tallinn: ScanBalt Forum, 2010, pp.47-47.
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