Synthesis, Structure and Cytotoxicity of 3-C, N, S, Se Substituted Benzo[B]Selenophene Derivatives

European Journal of Medicinal Chemistry 2011
P. Arsenyan, E. Paegle, Sergejs Beļakovs, I. Shestakova, E. Jaschenko, E. Domracheva, J. Popelis

Synthesis, molecular structure and cytotoxic activity of a series of 3-C, N, S, Se substituted benzo[b]selenophene derivatives on human fibrosarcoma HT-1080, mouse hepatoma MG-22A, and mouse fibroblasts 3T3 cell lines are described. The correlation between compound LD(50) 3T3 fibroblast cell line and HT-1080 morphology was shown.

Keywords
Arylation; Amination; Benzo[b]selenophene; Cytotoxic activity; Morphology; Selenium; X-ray
DOI
10.1016/j.ejmech.2011.05.008
Hyperlink
http://www.sciencedirect.com/science/article/pii/S0223523411003709

Arsenyan, P., Paegle, E., Beļakovs, S., Shestakova, I., Jaschenko, E., Domracheva, E., Popelis, J. Synthesis, Structure and Cytotoxicity of 3-C, N, S, Se Substituted Benzo[B]Selenophene Derivatives. European Journal of Medicinal Chemistry , 2011, Vol.46, Iss.8, pp.3434-3443. ISSN 0223-5234. Available from: doi:10.1016/j.ejmech.2011.05.008

Publication language
English (en)