Synthesis and Reactions of 2,6-Bis-(4-substituted-1,2,3-triazol-1-yl)-9-(beta-D-arabinofuranosyl)purines

XVth Symposium on Chemistry of Nucleic Acid Components: Collection, Symposium Series 2011
Armands Kovaļovs, Māris Turks, Ērika Bizdēna

Facile synthesis of protected 2,6-diazidopurine arabinonucleoside starting from tetra-O-acetyl-D-arabinose and 2,6-dichloropurine via 1-bromo-tri-O-acetylarabinose has been developed. A series of 2,6-bis-(1,2,3-triazolyl)-substituted purine arabinonucleosides has been synthesized in Cu(I) catalysed Huisgen 1,3-dipolar azide-alkyne cycloaddition reactions in moderate to good yields.

Keywords
purines, click reaction, bis-triazolyl-nucleosides

Kovaļovs, A., Turks, M., Bizdēna, Ē. Synthesis and Reactions of 2,6-Bis-(4-substituted-1,2,3-triazol-1-yl)-9-(beta-D-arabinofuranosyl)purines. In: XVth Symposium on Chemistry of Nucleic Acid Components: Collection, Symposium Series, Czech Republic, Česky Krumlov, 5-10 June, 2011. Prague: Institute of Organic Chemistry and Biochemistry, 2011, pp.304-306.

Publication language
English (en)