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Publikācija: Model Based Escherichia Coli Bacteria Fermentation

Publication Type Conference paper
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Model Based Escherichia Coli Bacteria Fermentation
Field of research 2. Engineering and technology
Sub-field of research 2.11 Other engineering and technologies
Authors Oskars Grīgs
Juris Vanags
Vytautas Galvanauskas
Keywords Biotechnology, fermentation, process control, Escherichia coli
Abstract Model-based fed-batch cultivation approach of non-recombinant Escherichia coli bacteria are presented. Aim of current research was to utilize mathematical modeling of fermentation process to precisely calculate exponential feeding rates for succesive biomass growth processes. In this case were used models which state mass balance for biomass (X), substrate (S), acetate (A), vessel volume (V) and additional model for bioreactor mass flows (F). In such a way we achieved controlled and predefined biomass growth according to the process model. Using well defined fed-batch media which consisted from salts and glucose, in most successive runs were achieved E. coli cultures with biomass concentrations up to 60 g/l.
Reference Grīgs, O., Vanags, J., Galvanauskas, V. Model Based Escherichia Coli Bacteria Fermentation. In: Abstracts of the 52nd International Scientific Conference of Riga Technical University : Section: Material Science and Applied Chemistry, Latvia, Rīga, 13-15 October, 2011. Riga: RTU Publishing House, 2011, pp.94-94. ISBN 978-9934-10-181-6.
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