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Publikācija: Controlled Release of Local Anesthetic from Calcium Phosphate Bone Cements

Publication Type Scientific article indexed in SCOPUS or WOS database
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Controlled Release of Local Anesthetic from Calcium Phosphate Bone Cements
Field of research 2. Engineering and technology
Sub-field of research 2.5 Materials engineering
Authors Zilgma Irbe
Dagnija Loča
Daina Vempere
Līga Bērziņa-Cimdiņa
Keywords Biomaterials, bone cement, calcium phosphate cements, calcium phosphates, drug delivery
Abstract Novel lidocaine containing calcium phosphate bone cements have been developed. Lidocaine release kinetics of these cements have been evaluated. Calcium phosphate cements have a great potential for local drug delivery. Release of local anesthetic, such as lidocaine, at the implant site can be useful for reducing pain immediately after implantation. In thiswork a local anesthetic – lidocaine hydrochloride –was incorporated intoα-tricalciumphosphate cement. Lidocaine release profilewas dependent on cement components used. All cements were characterized by an initial burst release,which can be correlatedwith cement pH values, followed by gradual drug release. Drug release continued for up to 6 days and was slower, if cement pH was higher. Addition of lidocaine hydrochloride accelerated setting and changed microstructure of the set cement.
DOI: 10.1016/j.msec.2012.04.069
Hyperlink: http://www.sciencedirect.com/science/article/pii/S0928493112001993 
Reference Irbe, Z., Loča, D., Vempere, D., Bērziņa-Cimdiņa, L. Controlled Release of Local Anesthetic from Calcium Phosphate Bone Cements. Materials Science and Engineering C, 2012, Vol.32, Iss.6, pp.1690-1694. ISSN 0928-4931. Available from: doi:10.1016/j.msec.2012.04.069
Additional information Citation count:
ID 13334