Inorganic Nanoparticle as a Carrier for Hepatitis B Viral Capsids

2012
Jurijs Dehtjars, Marina Romanova, Anna Kačanovska, Dace Skrastiņa, Regīna Reinhofa, Pauls Pumpēns, Aloizijs Patmalnieks

Virus like particles (VLP) are used to transport immune response-modulating agents to target cells to treat them. In order to deliver a high concentration of VLP to the cell, a number of VLP can be attached to a nanoparticle to be used as a nanolorry. In this study, SiO2 nanoparticles were attached to Hepatitis B VLP. Spectrophotometry measurements, electron, and fluorescent microscopy evidence showed that the SiO2 – Hepatitis B VLP complexes were formed.

Keywords
virus like particles, silica, nanoparticles, immunomodulation, optical absorbance
DOI
10.1007/978-94-007-2488-4_23
Hyperlink
http://link.springer.com/chapter/10.1007/978-94-007-2488-4_23

Dehtjars, J., Romanova, M., Kačanovska, A., Skrastiņa, D., Reinhofa, R., Pumpēns, P., Patmalnieks, A. Inorganic Nanoparticle as a Carrier for Hepatitis B Viral Capsids. In: Technological Innovations in Sensing and Detection of Chemical, Biological, Radiological, Nuclear Threats and Ecological Terrorism. NATO Science for Peace and Security Series A: Chemistry and Biology. A.Vaseashta, E.Braman, P.Susmann ed. Dordrecht: Springer Netherlands, 2012. pp.221-225. ISBN 978-94-007-2487-7. e-ISBN 978-94-007-2488-4. ISSN 1874-6489. Available from: doi:10.1007/978-94-007-2488-4_23

Publication language
English (en)