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Publikācija: Click

Publication Type Conference paper
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Click, Substitute and Fluoresce: Synthesis and Applications of 2,6-Di-(1,2,3-triazolyl)-purine Nucleosides
Field of research 1. Natural sciences
Sub-field of research 1.4 Chemical sciences
Authors Irina Novosjolova
Armands Kovaļovs
Inga Bižāne
Ērika Bizdēna
Māris Turks
Keywords ditriazolylpurine nucleosides, 1,3-dipolar cycloaddition reaction, fluorescence
Abstract A novel class of ditriazolylpurine nucleosides were ob-tained from 2,6-diazido precursors via copper catalyzed azide-alkyne cycloaddition. These intermediates ap-peared to be very reactive towards N- and S-nucleophiles and thus selectively gave C(6)-substituted analogs with triazolyl moiety at C(2)-position. The latter products exhibit interesting fluorescence properties.
Hyperlink: http://www.is3na.org/assets/events/Category%203-Nucleos%28t%29ide%20Probes%20%28109-153%29.pdf#page=26 
Reference Novosjolova, I., Kovaļovs, A., Bižāne, I., Bizdēna, Ē., Turks, M. Click, Substitute and Fluoresce: Synthesis and Applications of 2,6-Di-(1,2,3-triazolyl)-purine Nucleosides. In: XX International Roundtable on Nucleosides Nucleotides and Nucleic Acids: Poster Abstracts, Canada, Montreal, 5-9 August, 2012. [S.l.]: IS3NA, 2012, pp.134-134.
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ID 13632