Structural Hybrids: Combining the Best of Sugars, Peptides, and Heterocycles
13th Belgian Organic Synthesis Symposium: Programme & Book of Abstracts 2012
Vitālijs Rjabovs, Māris Turks

Over time, 1,2,3-triazoles as well as sugar amino acids were addressed to mimic both the amide bonds of peptides and the foldamer abilities of the latter. Acetonide protected pento- and hexofuranoses are stereochemically defined molecular scaffolds that impose certain rigidity to the oligomeric structures made from them. Connection with an amide linkage provides open sites for the formation of intramolecular hydrogen bonds when incorporated in the larger molecules Herein we present the synthesis of furanose-based amide- and triazole-linked saccharopeptides I and II.


Keywords
sugars, peptides, heterocycles, mimetics, click chemistry

Rjabovs, V., Turks, M. Structural Hybrids: Combining the Best of Sugars, Peptides, and Heterocycles. In: 13th Belgian Organic Synthesis Symposium: Programme & Book of Abstracts, Belgium, Leuven, 15-20 July, 2012. Leuven: Katholieke Universiteit Leuven, 2012, pp.320-320.

Publication language
English (en)
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