Molecular and Crystal Structure of Sildenafil Base

Zeitschrift für Naturforschung B 2012
Dmitrijs Stepanovs, Anatolijs Mišņovs

Sildenafil citrate monohydrate, well known as Viagra®, is a drug for the treatment of erectile dysfunction. Here we present the X-ray crystal structure of the sildenafil base, C22H30N6O4S. The compound crystallizes in the monoclinic system, space group P21/c with the unit cell parameters a = 17.273(1), b=17.0710(8), c=8.3171(4) A° , β =99.326(2), Z = 4, V = 2420.0(3) A° 3. A comparison with the known crystal structures of sildenafil citrate monohydrate and sildenafil saccharinate is also presented.

Keywords
X-Ray; Crystal Structure; Sildenafil; Viagra
DOI
10.5560/ZNB.2012-0073
Hyperlink
http://www.znaturforsch.com/ab/v67b/0073.htm

Stepanovs, D., Mišņovs, A. Molecular and Crystal Structure of Sildenafil Base. Zeitschrift für Naturforschung B, 2012, 67b, pp.491-494. ISSN 0932-0776. Available from: doi:10.5560/ZNB.2012-0073

Publication language
English (en)