The subject of current research is modification of surface properties in nano scale with aim to improve poly methyl metha acrylate performance for biomedical applications where interaction between material and surrounding environment is critical, e.g. contact lenses, dental applications, bone cement and many others. Charge on materials surface is strongly related to surface energy which in turn influences surface adhesion property and wettability property. Prosthetic PMMA surface properties including related biocompatibility are affected during time due to mechanical impact – wear between eye lense and eye lid; surrounding factors – wind, sand, sun. Mentioned factors lead to discomfort, inflammations for patients in case of eye lenses; to poor attachment capability in case of dental applications therefore many are trying to improve PMMA material.Results show that it might be possible to regulate surface properties also of commercial PMMA that would open new possibilities in both medical and non-medical fields.