Global competitiveness, economic slack and uncertainty of business environment give birth to a number of significant questions which are related to the quality management of business in small and medium enterprises and to their capability to function successfully in a long-term perspective. An enterprise itself develops in a cyclic mode. In order to provide sustainable development of an enterprise in dynamically changing environment of contemporary business, methods based on new approaches should be used in its management. The authors show the opportunities of acquiring new knowledge by businessmen using properly structured basis of knowledge on sustainable performance management of an enterprise using the objective laws of its life cycle. They have elaborated a special method of workplace training of businessmen; this approach enables to ensure sustainable business in accordance with the peculiarities of the stage of the small and medium-sized enterprise life cycle.