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Publikācija: Novel Concepts of “Niche-Relief” and Niche-Voltage” for Stem Cells as a Base of Bone and Hematopoietic Tissues Biomimetic Engineering

Publication Type Full-text conference paper published in conference proceedings indexed in SCOPUS or WOS database
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Novel Concepts of “Niche-Relief” and Niche-Voltage” for Stem Cells as a Base of Bone and Hematopoietic Tissues Biomimetic Engineering
Field of research 1. Natural sciences
Sub-field of research 1.3 Physical sciences
Authors Jurijs Dehtjars
I. Khlusov
M. Khlusova
E. Gostichev
Yu. Sharkeev
V. Pichugin
Keywords niche-relief, niche-voltage, hematopoietic
Abstract An affect of relief features and quantitative variables of artificial surfaces on structural-functional status of human lung prenatal stromal cells (HLPSC) and remodeling of Balb/c mice bone/bone marrow system have been studied. Implants with rough (Ra>2 μm) calcium phosphate micro-arc coatings have structural-functional sites (micro-regions) named “niches-relief” which are necessary for maturation and differentiation of HLPSC into secreting osteoblasts in shortterm culture. Maximal remodeling of mouse bone/bone marrow system in 45-day subcutaneous heterotopic test in vivo is also noted under optimal parameter (average index of cellular alkaline phosphatase area to artificial micro-region area is about 43 %) of osteogenic niche in vitro. Probable physical mechanism of osteogenic niche functioning has been determined. It correlates with increasing of electron work function supplied with a negative charge of calcium phosphate nanorelief in the sockets (artificial “niches”). “Niche-voltage” concept for bone tissue biomimetic engineering was proposed.
DOI: 10.1007/978-3-642-34197-7_26
Hyperlink: http://rd.springer.com/chapter/10.1007/978-3-642-34197-7_26 
Reference Dehtjars, J., Khlusov, I., Khlusova, M., Gostichev, E., Sharkeev, Y., Pichugin, V. Novel Concepts of “Niche-Relief” and Niche-Voltage” for Stem Cells as a Base of Bone and Hematopoietic Tissues Biomimetic Engineering. In: IFMBE Proceedings. Vol.38: International Symposium on Biomedical Engineering and Medical Physics (ISBEMP 2012), Latvia, Riga, 10-12 October, 2012. Berlin: Springer Berlin Heidelberg, 2013, pp.99-102. ISBN 978-3-642-34196-0. e-ISBN 978-3-642-34197-7. ISSN 1680-0737. e-ISSN 1433-9277. Available from: doi:10.1007/978-3-642-34197-7_26
Additional information Citation count:
ID 14405