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Publikācija: Novel Concepts of “Niche-Relief” and Niche-Voltage” for Stem Cells as a Base of Bone and Hematopoietic Tissues Biomimetic Engineering

Publication Type Conference paper
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Novel Concepts of “Niche-Relief” and Niche-Voltage” for Stem Cells as a Base of Bone and Hematopoietic Tissues Biomimetic Engineering
Field of research 1. Natural sciences
Sub-field of research 1.3 Physical sciences
Authors Jurijs Dehtjars
I. Khlusov
M. Khlusova
E. Gostichev
Yu. Sharkeev
V. Pichugin
Keywords niche-relief, niche-voltage, hematopoietic
Abstract Currently, a lot of publications, mainly as hypotheses, were dedicated to niches for hemopoietic stem cells (HSC). Multipotent mesenchymal stromal cells (MMSC) are treated as important cell component of HSC niches [1]. At the same time, the circumstance that discussion of existence of niches determining fate of MMSC themselves just appears in literature sets at gaze [2]. Pilot experimental data about existence and dimensions of niches for osteogenic differentiation of MMSC, their close dependence on quantitative variables of bone mineral substance relief were recently obtained by us [3]. In this connection, investigation of the relief features effects of model mineral matrix on structural-functional conditions of human MMSC and remodeling of bone/bone marrow system in mice was of great interest.
Hyperlink: http://scientific-conference2012.rtu.lv/sites/default/files/RTU_Conference_2012.pdf 
Reference Dehtjars, J., Khlusov, I., Khlusova, M., Gostichev, E., Sharkeev, Y., Pichugin, V. Novel Concepts of “Niche-Relief” and Niche-Voltage” for Stem Cells as a Base of Bone and Hematopoietic Tissues Biomimetic Engineering. In: Riga Technical University 53rd International Scientific Conference: Dedicated to the 150th Anniversary and the 1st Congress of World Engineers and Riga Polytechnical Institute / RTU Alumni: Digest, Latvia, Riga, 10-12 October, 2012. Riga: RTU, 2012, pp.642-642. ISBN 978-9934-10-360-5.
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