Generally human thermal comfort depends on combinations of clothing structure and chemical nature of fibers, external conditions (ambient temperature, humidity etc.) and factors related to wearer (metabolism, physical activities etc.). Thermal comfort of a clothing system is associated with the thermal balance of the body and its thermoregulatory responses to the dynamic interactions with the clothing and the environment, and can be quantified in terms of Met and Clo units. One of the important functions of clothing is providing of adequate thermal comfort for wellness and high performance. For this research there is developed smart clothing with an integrated human microclimate regulating electrical system. Generally the clothing contains: Peltier coolers, which provide cooling effect; electronic control system with heat sensor – thermistor, which controls the optimal operating parameters, and energy source.