Synthesis of 3-{3-[(4-Methylcyclohex-3-Enyl-Carbonyl)Amino]-4-Oxo-3,4-Dihydroquinazolin-2-Yl}Propanoic Acid Anilides

Chemistry of Heterocyclic Compounds 2012
Daina Zicāne, Irisa Rāviņa, Zenta Tetere, Inese Rijkure

With the aim of discovering potential diuretic agents amongst quinazoline anilides we have prepared anilides of 3-{3-[(4-methylcyclohex-3-enylcarbonyl)amino]-4-oxo-3,4-dihydroquinazolin-2-yl}propanoic acid. Optimal conditions for obtaining of the starting acid have been established, and anilides have been synthesized by the mixed anhydrides method.

Keywords
anilides, hydrazides, mixed anhydrides, propionic acid, quinazolines, succinic anhydride
DOI
10.1007/s10593-012-0997-z
Hyperlink
http://link.springer.com/article/10.1007%2Fs10593-012-0997-z

Zicāne, D., Rāviņa, I., Tetere, Z., Rijkure, I. Synthesis of 3-{3-[(4-Methylcyclohex-3-Enyl-Carbonyl)Amino]-4-Oxo-3,4-Dihydroquinazolin-2-Yl}Propanoic Acid Anilides. Chemistry of Heterocyclic Compounds, 2012, Vol.48, Iss.2, pp.358-361. e-ISSN 1573-8353. ISSN 0009-3122. Available from: doi:10.1007/s10593-012-0997-z

Publication language
English (en)