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Publikācija: The Effect of pH on Polymorph Formation of the Pharmaceutically Active Compound Tianeptine

Publication Type Scientific article indexed in SCOPUS or WOS database
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language The Effect of pH on Polymorph Formation of the Pharmaceutically Active Compound Tianeptine
Field of research 1. Natural sciences
Sub-field of research 1.4 Chemical sciences
Authors Liāna Orola
M.V. Veidis
I. Sarcevica
A. Actiņš
Sergejs Beļakovs
A. Platonenko
Keywords Tianeptine; Polymorph; Crystallization; pH; Crystal structure; X-ray diffractometry
Abstract The anti-depressant pharmaceutical tianeptine has been investigated to determine the dynamics of polymorph formation under various pH conditions. By varying the pH two crystalline polymorphs were isolated. The molecular and crystal structures have been determined to identify the two polymorphs. One polymorph is an amino carboxylic acid and the other polymorph is a zwitterion. In the solid state the tianeptine moieties are bonded through hydrogen bonds. The zwitterion was found to be less stable and transformed to the acid form. During this investigation an amorphous form was identified.
DOI: 10.1016/j.ijpharm.2012.04.061
Hyperlink: http://www.sciencedirect.com/science/article/pii/S0378517312004073 
Reference Orola, L., Veidis, M., Sarcevica, I., Actiņš, A., Beļakovs, S., Platonenko, A. The Effect of pH on Polymorph Formation of the Pharmaceutically Active Compound Tianeptine. International Journal of Pharmaceutics, 2012, Vol.432, Iss.1–2, pp.50-56. ISSN 0378-5173. Available from: doi:10.1016/j.ijpharm.2012.04.061
Additional information Citation count:
ID 15146