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Publikācija: In Vitro Evaluation of Osteoblast Cell Behavior and Antimicrobial Properties of Biphasic Calcium Phosphate Ceramics

Publication Type Full-text conference paper published in conference proceedings indexed in SCOPUS or WOS database
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language In Vitro Evaluation of Osteoblast Cell Behavior and Antimicrobial Properties of Biphasic Calcium Phosphate Ceramics
Field of research 2. Engineering and technology
Sub-field of research 2.5 Materials engineering
Authors Dagnija Loča
Arita Dubņika
Aigars Reinis
Nadežda Romančikova
Keywords biphasic calcium phosphate ceramics, bioceramics, hydroxyapatite, β-tricalcium phosphate
Abstract Calcium phosphate ceramic materials in form of hydroxylapatite (HAp) and β-tricalcium phosphate (TCP) are good candidates for bone substitution and regeneration. Ma-jority of methods used for biphasic calcium phosphate (mix-ture of HAp and TCP) preparation includes synthesis of calci-um deficient apatite, not so often mechanical mixing of HAp and TCP is applied. The aim of this work was to evaluate the effect of HAp/TCP ratio as well as the impact of biphasic cal-cium phosphate (BCP) preparation technique on osteoblast cell behavior and ceramic antimicrobial properties. Results showed that BCP composite samples supported much higher proliferation rate of osteoblast cells as those of pure HAp or TCP. The best result was observed for BCP samples with HAp/TCP ratio 60/40. BCP preparation technique significantly does not affect the cell attachment on the surface of BCP sam-ples, while influence on colonization intensity of bacteria was observed. Results indicated that the use of pure HAp or BCP ceramics as implant materials can cause less inflammatory risks compared to the pure TCP ceramics.
DOI: 10.1007/978-3-642-34197-7_49
Hyperlink: http://link.springer.com/chapter/10.1007%2F978-3-642-34197-7_49# 
Reference Loča, D., Dubņika, A., Reinis, A., Romančikova, N. In Vitro Evaluation of Osteoblast Cell Behavior and Antimicrobial Properties of Biphasic Calcium Phosphate Ceramics. In: IFMBE Proceedings. Vol.38: International Symposium on Biomedical Engineering and Medical Physics, Latvia, Riga, 10-12 October, 2012. Berlin: Springer Berlin Heidelberg, 2013, pp.186-190. ISBN 978-3-642-34196-0. e-ISBN 978-3-642-34197-7. ISSN 1680-0737. Available from: doi:10.1007/978-3-642-34197-7_49
Additional information Citation count:
ID 15713