X-Ray Structure Analysis of a Solid Solution of Milbemycins A3 and A4

Natural Product Research 2013
Ērika Bizdēna, Sergejs Beļakovs, Māra Jure, Inguna Grīnšteine, Viktors Kumpiņš, Māris Turks

Milbemycins A3 and A4 are pharmaceutically and agriculturally useful macrolides isolated from Streptomyces species. The molecular structures of the title compounds were unambiguously established by a single crystal X-ray analysis of the solid solution of both compounds. The crystals present trigonal system, space group P32 with Z = 3, unit cell dimensions: a = 12.2211(4), c = 17.5372(7) Å; V = 2268.4(1) Å3, μ = 0.082 mm–1; d = 1.183 g•cm−3. Interesting system of intramolecular hydrogen bonds and weak intermolecular CH∙∙∙O type hydrogen bond were observed in the solid state.

Keywords
milbemycin A3; milbemycin A4; X-ray structure; solid solution
DOI
10.1080/14786419.2013.791820
Hyperlink
http://www.tandfonline.com/doi/abs/10.1080/14786419.2013.791820#.Uopry7HiXIU

Bizdēna, Ē., Beļakovs, S., Jure, M., Grīnšteine, I., Kumpiņš, V., Turks, M. X-Ray Structure Analysis of a Solid Solution of Milbemycins A3 and A4. Natural Product Research, 2013, Vol.27, Iss.20, pp.1936-1939. e-ISSN 1478-6427. ISSN 1478-6419. Available from: doi:10.1080/14786419.2013.791820

Publication language
English (en)