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Publikācija: Crystal and Molecular Structure and Stability of Isoniazid Cocrystals with Selected Carboxylic Acids

Publication Type Publication (anonimusly reviewed) in a journal with an international editorial board indexed in other databases
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Crystal and Molecular Structure and Stability of Isoniazid Cocrystals with Selected Carboxylic Acids
Field of research 1. Natural sciences
Sub-field of research 1.4 Chemical sciences
Research platform None
Authors I. Sarcevic
Liāna Orola
M.V. Veidis
A. Podjava
Sergejs Beļakovs
Keywords
Abstract Reaction of isoniazid with benzoic acid, sebacic acid, suberic acid, and cinnamic acid results in formation of cocrystals. Two polymorphs of isoniazid–suberic acid and two polymorphs of isoniazid–cinnamic acid cocrystals were isolated. Crystal structure analysis shows the presence of a pyridine–carboxylic acid synthon in the studied cocrystals. The hydrazide group of isoniazid participates in N–H···O and N–H···N hydrogen bond formation, producing different supramolecular synthons. The stability study of isoniazid cocrystals has been performed over a 22 week period. A comparison of melting points of isoniazid–dicarboxylic acid 2:1 cocrystals shows the decrease of melting point with an increasing length of the acid. Solubility of isoniazid–carboxylic acid cocrystals tends to increase with increasing solubility of the acid.
DOI: 10.1021/cg301356h
Hyperlink: http://pubs.acs.org/doi/abs/10.1021/cg301356h 
Reference Sarcevic, I., Orola, L., Veidis, M., Podjava, A., Beļakovs, S. Crystal and Molecular Structure and Stability of Isoniazid Cocrystals with Selected Carboxylic Acids. Crystal Growth & Design, 2013, Vol. 13, No. 3, pp.1082-1090. ISSN 1528-7483. e-ISSN 1528-7505. Available from: doi:10.1021/cg301356h
ID 17031