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Publikācija: Calcium Phosphate Bone Cements Reinforced with Biodegradable Polymer Fibres for Drug Delivery

Publication Type Conference paper
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Calcium Phosphate Bone Cements Reinforced with Biodegradable Polymer Fibres for Drug Delivery
Field of research 2. Engineering and technology
Sub-field of research 2.5 Materials engineering
Authors Dagnija Loča
Zilgma Irbe
Ivita Bistrova
Līga Bērziņa-Cimdiņa
Keywords Calcium phosphate, bone cements, drug delivery
Abstract Calcium phosphate based biomaterials are prospective materials for the bone defect repair and regeneration. Among them, calcium phosphate bone cements (CPC) are the most suitable for local drug delivery, as drugs can be easily incorporated into the cement, while it is in paste form. To control the drug release from CPC, the drugs can be encapsulated in biodegradable polymers. The main disadvantage of CPC is their low mechanical strength [3]. Drug capsules may act as defects in matrix lowering the strength of the cements. To improve the mechanical properties of α-tricalcium phosphate (α-TCP) based CPC intended for drug delivery, cements were reinforced with biodegradable fibres. The effect of drug loaded microcapsules and reinforcing fibres on mechanical properties of CPC was investigated.
Reference Loča, D., Irbe, Z., Bistrova, I., Bērziņa-Cimdiņa, L. Calcium Phosphate Bone Cements Reinforced with Biodegradable Polymer Fibres for Drug Delivery. In: BALTMATTRIB 2013: 22nd International Baltic Conference of Engineering Materials & Tribology: Book of Abstracts, Latvia, Rīga, 14-15 November, 2013. Rīga: Latvijas Materiālu Pētīšanas biedrība, 2013, pp.32-32. ISBN 978-9984-49-987-1.
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