Synthesis of 4H-Pyran Derivatives under Solvent-Free and Grinding Conditions

Synthetic Communications 2013
R. Smits, Sergejs Beļakovs, Aiva Plotniece, Gundars Duburs

Based on x-ray diffraction analysis, we have proved that the recently published results for ethyl 6-amino-5-cyano-4-aryl-1,4-dihydropyridine-3-carboxylate synthesis is in fact an environmentally friendly synthesis of 6-amino-5-cyano-4-aryl-4H-pyran derivatives using a multicomponent room-temperature grinding procedure of ethyl acetoacetate, [(2-aryl)methylene]malononitriles, and ammonium acetate.

Keywords
Green synthesis, grinding, 4H-pyran derivatives, multicomponent reactions, solvent-free, x-ray diffraction
DOI
10.1080/00397911.2012.716484
Hyperlink
https://www.tandfonline.com/doi/abs/10.1080/00397911.2012.716484

Smits, R., Beļakovs, S., Plotniece, A., Duburs, G. Synthesis of 4H-Pyran Derivatives under Solvent-Free and Grinding Conditions. Synthetic Communications, 2013, Vol. 43, No. 4, pp.465-475. ISSN 0039-7911. e-ISSN 1532-2432. Available from: doi:10.1080/00397911.2012.716484

Publication language
English (en)