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Publikācija: Structural Proof of Tetrazolo[1

Publication Type Scientific article indexed in SCOPUS or WOS database
Funding for basic activity Unknown
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Publication language English (en)
Title in original language Structural Proof of Tetrazolo[1,5-A]Quinazoline Derivatives and Their Application in the Synthesis of 4-Amino-2-(1,2,3-Triazol-1-Yl)-Quinazolines
Field of research 1. Natural sciences
Sub-field of research 1.4 Chemical sciences
Authors Agnese Kalniņa
Ērika Bizdēna
Gļebs Kiseļovs
Anatolijs Mišņovs
Māris Turks
Keywords
Abstract 5-Azidotetrazolo[1,5-a]quinazoline (formally known as 2,4-diazidoquinazoline) undergoes regioselective nucleophilic aromatic substitution with amines at C(5) and provides corresponding 5-amino derivatives of tetrazolo[1,5-a]quinazoline. For the first time the molecular structure of the latter tricyclic system is unambiguously proved by X-ray diffraction analysis. Tautomeric equilibrium between tetrazolo[1,5-a]quinazolines and 2-azido-quinazolines permits their use in the copper catalyzed azide-alkyne 1,3-dipolar cycloaddition reaction. In this way a series of N4-substituted derivatives of 4-amino-2-(1,2,3-triazol-1-yl)-quinazolines were obtained.
Reference Kalniņa, A., Bizdēna, Ē., Kiseļovs, G., Mišņovs, A., Turks, M. Structural Proof of Tetrazolo[1,5-A]Quinazoline Derivatives and Their Application in the Synthesis of 4-Amino-2-(1,2,3-Triazol-1-Yl)-Quinazolines. Химия гетероциклических соединений, 2013, 11, pp.1797-1803. ISSN 0132-6244.
Additional information Citation count:
  • Scopus  0
ID 17334