In this paper, the remote sensing monitoring of natural and technological objects is represented as a concept of integrated modelling and simulation of the processes of the complex technical–organizational system (CTOS). The main goal of the study is to use in practice predetermined modelling. The paper considers the technology of remote sensing monitoring of the natural and technological objects, methodological foundations of the integrated modelling and simulation, and the process of CTOS operation. Special attention is devoted to the continuity of the model and object solving practical issues. Moreover, the results of CTOS remote sensing monitoring make it possible to adapt models of this system to a changing environment.