Research is dedicated to computer-based decisionmaking technology intended for screening diagnostics and its basic principle implementation in the Mobile Telemedicine Screening Complex (MTSC). The decision-making logic is based on two main information flows. One is the main stream, including objective measurement results from MTSC hardware, and, the other – the subjective patient interactive questionnaire, including complaints, feelings, risk factors and conformation of existing chronic diseases. The paper provides the description of decision-making technology starting with the exploration of the flow of mutual obligations and ending with decision-making rules to produce the final decision.