Milbemycins A3 and A4 Isolation, X-ray Studies, Semi-synthetic Analogs

ChemMedChem 2014
Jevgeņija Lugiņina, Ērika Bizdēna, Viktors Kumpiņš, Sergejs Beļakovs, Māra Jure, Inguna Grīnšteine, Ainars Leonciks, Māris Turks

Among natural products, polypropionates represent an important class that can be found as common products of metabolism in plants, bacteria, insects, fungi and marine organisms. The group includes plant flavonoids, fungal aflatoxins, as well as many compounds that can inhibit the growth of bacteria, viruses, fungi, parasites or human tumor cells.[1] Indeed, at least a hundred compounds from approximately 10000 known polypropionate natural products possess drug activity.[2]

Keywords
Milbemycins, semi-synthetic analogs

Lugiņina, J., Bizdēna, Ē., Kumpiņš, V., Beļakovs, S., Jure, M., Grīnšteine, I., Leonciks, A., Turks, M. Milbemycins A3 and A4 Isolation, X-ray Studies, Semi-synthetic Analogs. ChemMedChem, 2014, Special Issue, pp.330-330. e-ISSN 1860-7187.

Publication language
English (en)