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Publikācija: Calcium Phosphate Bone Cements Reinforced with Biodegradable Polymer Fibres for Drug Delivery

Publication Type Scientific article indexed in SCOPUS or WOS database
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Calcium Phosphate Bone Cements Reinforced with Biodegradable Polymer Fibres for Drug Delivery
Field of research 2. Engineering and technology
Sub-field of research 2.5 Materials engineering
Authors Zilgma Irbe
Dagnija Loča
Ivita Bistrova
Līga Bērziņa-Cimdiņa
Keywords
Abstract It is well known that calcium phosphate bone cements set at low temperatures, therefore a wide range of drugs can be introduced within these cements. Calcium phosphate bone cements are generally regarded as having low mechanical strength that can be further lowered, if large amounts of drugs are incorporated. In this case additional porosity will occur and cause mechanical instability of bone cements. Thus in the current research calcium phosphate bone cements were reinforced with poly lactic-co-glycolic acid or silk microfibers and composite application towards the local vancomycin (an antibiotic) delivery was evaluated. Results show that by reinforcing a-tricalcium phosphate bone cements with biodegradable silk and poly lactic-co-glycolic acid fibres it was possible to increase cement compressive strength from 10 MPa up to 20 MPa. The burst release of vancomycin from the prepared cements was observed in the first 24 h, but afterwards vancomycin was gradually released in a linear way for more than 25 days.
DOI: 10.4028/www.scientific.net/KEM.604.184
Hyperlink: http://www.scientific.net/KEM.604.184 
Reference Irbe, Z., Loča, D., Bistrova, I., Bērziņa-Cimdiņa, L. Calcium Phosphate Bone Cements Reinforced with Biodegradable Polymer Fibres for Drug Delivery. Key Engineering Materials, 2014, Vol.604, pp.184-187. ISSN 1662-9795. Available from: doi:10.4028/www.scientific.net/KEM.604.184
Additional information Citation count:
ID 19008