Copper-Catalyzed Intermolecular C–H Amination of (Hetero)arenes via Transient Unsymmetrical λ3-Iodanes

Journal of the American Chemical Society 2014
Igors Sokolovs, Dmitrijs Lubriks, Edgars Sūna

A one-pot two-step method for intermolecular C–H amination of electron-rich heteroarenes and arenes has been developed. The approach is based on a room-temperature copper-catalyzed regioselective reaction of the in situ formed unsymmetrical (hetero)aryl-λ3-iodanes with a wide range of primary and secondary aliphatic amines and anilines.

Keywords
Aromatic compounds; Catalysis; Copper; Steel beams and girders Aliphatic amines; C-H amination; Electron-rich; Heteroarenes; One pot; Regioselective reactions; Room temperature; Two step method
DOI
10.1021/ja502174d
Hyperlink
http://pubs.acs.org/doi/abs/10.1021/ja502174d

Sokolovs, I., Lubriks, D., Sūna, E. Copper-Catalyzed Intermolecular C–H Amination of (Hetero)arenes via Transient Unsymmetrical λ3-Iodanes. Journal of the American Chemical Society, 2014, Vol.136, No.19, pp.6920-6928. ISSN 0002-7863. e-ISSN 1520-5126. Available from: doi:10.1021/ja502174d

Publication language
English (en)