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Publikācija: Cinnamic Acid Hydrogen Bonds to Isoniazid and N'-(Propan-2-Ylidene)Isonicotinohydrazide

Publication Type Scientific article indexed in SCOPUS or WOS database
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Cinnamic Acid Hydrogen Bonds to Isoniazid and N'-(Propan-2-Ylidene)Isonicotinohydrazide, an in situ Reaction Product of Isoniazid and Acetone
Field of research 1. Natural sciences
Sub-field of research 1.4 Chemical sciences
Authors I. Sarcevica
Liāna Orola
M.V. Veidis
Sergejs Beļakovs
Keywords cinnamic acid–isoniazid cocrystal; crystal structure; hydrogen bonding; in situ modification; modification of hydrogen bonding; pharmaceutically active compound
Abstract A new polymorph of the cinnamic acid-isoniazid cocrystal has been prepared by slow evaporation, namely cinnamic acid-pyridine-4-carbohydrazide (1/1), C9H8O2·C6H7N3O. The crystal structure is characterized by a hydrogen-bonded tetrameric arrangement of two molecules of isoniazid and two of cinnamic acid. Possible modification of the hydrogen bonding was investigated by changing the hydrazide group of isoniazid via an in situ reaction with acetone and cocrystallization with cinnamic acid. In the structure of cinnamic acid-N'-(propan-2-ylidene)isonicotinohydrazide (1/1), C9H8O2·C9H11N3O, carboxylic acid-pyridine O-H···N and hydrazide-hydrazide N-H···O hydrogen bonds are formed.
DOI: 10.1107/S2053229614003684
Hyperlink: http://onlinelibrary.wiley.com/doi/10.1107/S2053229614003684/abstract 
Reference Sarcevica, I., Orola, L., Veidis, M., Beļakovs, S. Cinnamic Acid Hydrogen Bonds to Isoniazid and N'-(Propan-2-Ylidene)Isonicotinohydrazide, an in situ Reaction Product of Isoniazid and Acetone. Acta Crystallographica Section C, 2014, Vol.70, Iss.4, pp.392-395. e-ISSN 2053-2296. Available from: doi:10.1107/S2053229614003684
Additional information Citation count:
ID 19212