Synthesis of Novel Quinazolinone-1,2,3-Triazole Conjugates
Journal of Chemical and Pharmaceutical Research
2014
Gerda Krastiņa,
Irisa Rāviņa,
Inese Mieriņa,
Daina Zicāne,
Māris Turks,
Zenta Tetere,
Ainārs Leončiks
Hybrid compounds of 2-styryl quinazolinone and 1,2,3-triazoles were synthesized via 1,3-dipolar azide-alkyne cycloaddition reaction from 3-(2-azidoethyl)quinazolinones and various alkynes, followed by Knoevenagel reaction between 2-methylquinazolinone-1,2,3-triazole conjugates and aromatic aldehydes. All quinazolinone-1,2,3-triazole hybrid compounds were tested for their antiradical and antibacterial activity, but did not show any significant activity.
Keywords
2-Styryl quinazolinone-1,2,3-triazole conjugate, Huisgen reaction, Knoevenagel condition, antiradical activity, antibacterial activity
Hyperlink
http://jocpr.com/vol6-iss12-2014/JCPR-2014-6-12-6-14.pdf
Krastiņa, G., Rāviņa, I., Mieriņa, I., Zicāne, D., Turks, M., Tetere, Z., Leončiks, A. Synthesis of Novel Quinazolinone-1,2,3-Triazole Conjugates. Journal of Chemical and Pharmaceutical Research, 2014, Vol. 6, No. 12, pp.6-14. ISSN 0975-7384.
Publication language
English (en)