Preparation of 6-Unsubstituted 3,4-Dihydropyrimidin-2(1H)-ones and 2-(Arylamino)pyrimidines

Химия гетероциклических соединений 2013
S. Terentjeva, D. Muceniece, Viesturs Lūsis

A series of new 6-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones have been obtained from methyl propiolate, as well as from methyl 3-diethylaminoacrylate, using the Biginelli reaction. By subsequent oxidation of the pyrimidine reing, clorination of the 2-oxo group, and substitution of the chlorine atom by an aromatic amine they have been converted into heretofore unknown 2-(arylamino)pyrimidines. 2-Oxo- and 2-(arylamino)pyrimidine-5-carboxylic acids also were obtained.

Keywords
2-oxo-1,2,3,4-tetrahydropyrimidines; 2-oxo-1,2-dihydropyrimidines; 2-chloropyrimidines; 2-(arylamino)pyrimidines; Biginelli reaction

Terentjeva, S., Muceniece, D., Lūsis, V. Preparation of 6-Unsubstituted 3,4-Dihydropyrimidin-2(1H)-ones and 2-(Arylamino)pyrimidines. Химия гетероциклических соединений, 2013, No. 12, pp.1896-1909. ISSN 0132-6244.

Publication language
English (en)