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Publikācija: Crystallized Nano-Sized Alpha-Tricalcium Phosphate from Amorphous Calcium Phosphate: Microstructure

Publication Type Scientific article indexed in SCOPUS or WOS database
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Crystallized Nano-Sized Alpha-Tricalcium Phosphate from Amorphous Calcium Phosphate: Microstructure, Cementation and Cell Response
Field of research 2. Engineering and technology
Sub-field of research 2.4 Chemical engineering
Authors Linda Vecbiškena
Kārlis-Agris Gross
Una Riekstiņa
Thomas Chung-Kuang Yang
Keywords amorphous calcium phosphate, alpha tricalcium phosphate, Rietveld refinement, cell response, bone cements, regenerative medicine
Abstract New insight on the conversion of amorphous calcium phosphate (ACP) to nano-sized alpha tricalcium phosphate (α-TCP) provides a faster pathway to calcium phosphate bone cements. In this work, synthesized ACP powders were treated with either water or ethanol, dried, crystallized between 700 and 800 °C, and then cooled at different cooling rates. Particle size was measured in a scanning electron microscope, but crystallite size calculated by Rietveld analysis. Phase composition and bonding in the crystallized powder was assessed by x-ray diffraction and Fourier-transform infrared spectroscopy. Results showed that 50 nm sized α-TCP formed after crystallization of lyophilized powders. Water treated ACP retained an unstable state that may allow ordering to nanoapatite, and further transition to β-TCP after crystallization and subsequent decomposition. Powders treated with ethanol, favoured the formation of pure α-TCP. Faster cooling limited the growth of β-TCP. Both the initial contact with water and the cooling rate after crystallization dictated β-TCP formation. Nano-sized α-TCP reacted faster with water to an apatite bone cement than conventionally prepared α-TCP. Water treated and freeze-dried powders showed faster apatite cement formation compared to ethanol treated powders. Good biocompatibility was found in pure α-TCP nanoparticles made from ethanol treatment and with a larger crystallite size. This is the first report of pure α-TCP nanoparticles with a reactivity that has not required additional milling to cause cementation.
DOI: 10.1088/1748-6041/10/2/025009
Hyperlink: http://iopscience.iop.org/1748-605X/10/2/025009/ 
Reference Vecbiškena, L., Gross, K., Riekstiņa, U., Chung-Kuang Yang, T. Crystallized Nano-Sized Alpha-Tricalcium Phosphate from Amorphous Calcium Phosphate: Microstructure, Cementation and Cell Response. Biomedical Materials, 2015, Vol.10, No.2, pp.1-10. ISSN 1748-6041. e-ISSN 1748-605X. Available from: doi:10.1088/1748-6041/10/2/025009
Additional information Citation count:
ID 20168