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Publikācija: Charge State of Silver Halide Colloids Determines the Antibacterial Activity in Amorphous Calcium Phosphate

Publication Type Scientific article indexed in SCOPUS or WOS database
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Charge State of Silver Halide Colloids Determines the Antibacterial Activity in Amorphous Calcium Phosphate
Field of research 2. Engineering and technology
Sub-field of research 2.5 Materials engineering
Authors Kārlis-Agris Gross
Daina Kalniņa
Zivile Stankeviciute
Vizma Nikolajeva
Keywords antimicrobial, calcium phosphates, silver iodide, hydroxyapatite, bone implants
Abstract Removal of bacteria is important not only at implantation, but after long-term implant/prosthesis use. This requires strategies that employ different approaches for combating bacteria. Halides have the potential of an additional mechanism, and together with silver may provide a more powerful antibacterial strategy. Silver iodide was synthesized as colloids with a positive and negative charge and incorporated into an amorphous calcium phosphate (ACP) to provide a possible greater antibacterial action. Colloids were characterized by FTIR spectroscopy and the charge measured by zeta potential. Phase analysis by X-ray diffraction patterns confirmed the formation of b-AgI nanoparticles. Minimum inhibitory concentrations (MIC) for preventing the growth of Staphylococcus aureus and Pseudomonas aeruginosa were lower for ACP containing negatively charged silver halides. Amorphous calcium phosphates with silver iodide exhibited good inhibition capacity. Solubility was determined by the increase in pH and the release of silver after 48 hours. The minimum bactericidal concentration (MBC) was also determined. This work has shown the effect of AgI charge in amorphous calcium phosphate for providing antibacterial action.
DOI: 10.4028/www.scientific.net/KEM.587.74
Hyperlink: http://www.scientific.net/KEM.587.74 
Reference Gross, K., Kalniņa, D., Stankeviciute, Z., Nikolajeva, V. Charge State of Silver Halide Colloids Determines the Antibacterial Activity in Amorphous Calcium Phosphate. Key Engineering Materials, 2014, Vol.587, pp.74-79. ISSN 1013-9826. e-ISSN 1662-9795. Available from: doi:10.4028/www.scientific.net/KEM.587.74
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ID 20310