Synthesis of 1,2,3-Triazole-Linked Glycohybrids in the Gluco-, Gulo-, and Allopyranose Series

Chemistry of Heterocyclic Compounds 2015
Jevgeņija Uzuleņa, Vitālijs Rjabovs, Antonio J. Moreno-Vargas, Māris Turks

3-C-Linked glycohybrids containing 1,2,3-triazole moiety as an intersugar linkage were synthesized. Biological activity of some of the compounds against glycosidases: α-fucosidases from bovine kidney, α-galactosidase from coffee beans, β-galactosidases from Escherichia coli and Aspergillus oryzae, α-glucosidase from yeast and rice, amyloglucosidases from Aspergillus niger, β-glucosidases from almonds, α-mannosidases from Jack beans, β-mannosidases from snail, and β-N-acetylglucosaminidases from Jack beans was tested.

Keywords
allose; glucose; gulose; 1,2,3-triazole; click chemistry; extended bistriazolyl linker; furanose–pyranose equilibrium; galactosidase activators
DOI
10.1007/s10593-015-1754-x
Hyperlink
http://hgs.osi.lv/index.php/hgs/article/view/2546

Uzuleņa, J., Rjabovs, V., Moreno-Vargas, A., Turks, M. Synthesis of 1,2,3-Triazole-Linked Glycohybrids in the Gluco-, Gulo-, and Allopyranose Series. Chemistry of Heterocyclic Compounds, 2015, Vol.51, No.7, pp.664-671. ISSN 0009-3122. e-ISSN 1573-8353. Available from: doi:10.1007/s10593-015-1754-x

Publication language
English (en)