The ability to induce formation of bonelike apatite on artificial bone implants in the human body is vital to the successful bonding between the implants and bone tissue. Immersion in simulated body fluid (SBF) is often used in vitro method for the first indication of potential bioactivity of biomaterials. Previous studies have shown that apatite-forming ability of titania is associated not only with its chemical composition and crystallinity, but also with its textural properties. The aim of present work was to evaluate the impact of different factors (e.g. microstructure, phase composition) on in vitro bioactivity of sintered titania ceramics.