Burr-like, Laser-Made 3D Microscaffolds for Tissue Spheroid Encagement

Biointerphases 2015
Paulis Danilevicius, Rodrigo Rezenda, Frederico Pereira, Alexandros Selimis, Vladimirs Kasjanovs, Pedro Noritomi, Jorge da Silva, Maria Chatzinikolaidou, Maria Farsai, Vladimir Mironov

The modeling, fabrication, cell loading, and mechanical and in vitro biological testing of biomimetic, interlockable, laser-made, concentric 3D scaffolds are presented. The scaffolds are made by multiphoton polymerization of an organic–inorganic zirconium silicate. Their mechanical properties are theoretically modeled using finite elements analysis and experimentally measured using a MicrosquisherVR . They are subsequently loaded with preosteoblastic cells, which remain live after 24 and 72 h. The interlockable scaffolds have maintained their ability to fuse with tissue spheroids. This work represents a novel technological platform, enabling the rapid, laser-based, in situ 3D tissue biofabrication.

Keywords
novel technological platform, enabling the rapid, laser-based, in situ 3D tissue biofabrication
DOI
10.1116/1.4922646
Hyperlink
http://scitation.aip.org/content/avs/journal/bip/10/2/10.1116/1.4922646

Danilevicius, P., Rezenda, R., Pereira, F., Selimis, A., Kasjanovs, V., Noritomi, P., da Silva, J., Chatzinikolaidou, M., Farsai, M., Mironov, V. Burr-like, Laser-Made 3D Microscaffolds for Tissue Spheroid Encagement. Biointerphases, 2015, Vol.10, pp.021011-1-021011-11. ISSN 1934-8630. e-ISSN 1559-4106. Available from: doi:10.1116/1.4922646

Publication language
English (en)