Molecular Salts of Propranolol with Dicarboxylic Acids: Diversity of Stoichiometry, Supramolecular Structures and Physicochemical Properties

CrystEngComm 2015
Dmitrijs Stepanovs, Māra Jure, A. Yanichev, Sergejs Beļakovs, Anatolijs Mišņovs

Crystallization of the drug propranolol with dicarboxylic acids yielded stable crystalline molecular salts with oxalic and fumaric acids in molar ratios of 1 : 1 and 2 : 1, and with maleic acid in a molar ratio of 1 : 1 only. The melting points of the salts obtained were roughly twice the melting point of pure propranolol, while their aqueous solubility was significantly higher in comparison to that of the propranolol base.

Keywords
Molecular salts of propranolol with dicarboxylic acids
DOI
10.1039/C5CE01408E
Hyperlink
http://pubs.rsc.org/en/Content/ArticleLanding/2015/CE/C5CE01408E#!divAbstract

Stepanovs, D., Jure, M., Yanichev, A., Beļakovs, S., Mišņovs, A. Molecular Salts of Propranolol with Dicarboxylic Acids: Diversity of Stoichiometry, Supramolecular Structures and Physicochemical Properties. CrystEngComm, 2015, Iss.17, pp.9023-9028. ISSN 1466-8033. Available from: doi:10.1039/C5CE01408E

Publication language
English (en)