Synthesis of 6-Perfluoroalkyl Analogues of Imatinib

Journal of Chemical Research 2015
S. Terentjeva, D. Muceniece, Viesturs Lūsis

6-Perfluoroalkyl pyrimidine derivatives of well known tyrosine kinase inhibitor imatinib have been synthesised from 1-(pyridin-3-yl)-3-perfluoroalkylbutane-1,3-diones by condensation with a 3-iodophenylguanidine and then by a Cu(I)-catalysed reaction with a 4-substituted benzamide.

Keywords
6-perfluoroalkyl analogues, imatinib
DOI
10.3184/174751915X14473498225894
Hyperlink
http://www.ingentaconnect.com/content/stl/jcr/2015/00000039/00000012/art00006

Terentjeva, S., Muceniece, D., Lūsis, V. Synthesis of 6-Perfluoroalkyl Analogues of Imatinib. Journal of Chemical Research, 2015, Vol.39, No.12, pp.701-705. ISSN 1747-5198. Available from: doi:10.3184/174751915X14473498225894

Publication language
English (en)