Within doctoral work were evaluated and applied various type and trajectory (substrate) feeding profiles for recombinant Escherichia coli BL21 (DE3) pBR327 hepatitis B core antigen producer biomass production fermentation process. Evalutaed feeding profiles are devised to be aplicable for the various biomass growth rate and yield fermentation proceses provission. Were introduced and aprobed evaluated feeding profile advanced on-line control methods – control depending on pO2 signal, and model predictive control, where both methods ensure higher process sfety and reproducibility standarts, desirable for GMP processes. Prior flask experiments were realized to detect temperature and pH influence on biomass yield, as well as to calculate biomass measurement precision and errors. The fermentation process modeling was made for the fed-batch profile calculations, where for the initial model identification, were used the data from flask experiments, and later for model re-identification the data from the 5 l bioreactor fed-batch fermentation proceses were used. Two models with different complexity were identified for flask and 5 l bioreactor scales, where in the more complex model, the accumulation of the acetate was taken into consideration. The identified simplified mathematical model, where no acetate influence was taken in to account, was used for realization of feeding profile model predictive control. In the review of the literature, the summarized and analyzed information correspond to sources published from year 1949 till 2016.