Spreading of Tissue Spheroids on an Electrospun Polyurethane Matrix

Biomedical Engineering 2016
E Koudan, E Bulanova, F Pereira, V Parfenov, Vladimirs Kasjanovs, U Hesuani, Vladimir Mironov

Tissue spheroids formed from fibroblasts using a micromolded nonadhesive hydrogel were located using a three dimensional (3D) bioprinter on the surface of a nanofibrous polyurethane matrix produced by electrospinning. It was shown that the tissue spheroids attach to the matrix surface within a few hours and completely flatten after several days, indicating high biocompatibility of the matrix used. Tissue structures formed by the attachment and spreading of tissue spheroids on an electrospun matrix are a new technological platform for biofabrication and 3D bioprinting of tissues and organs.

Keywords
Tissue spheroids, 3D bioprinting, Tissue structures
DOI
10.1007/s10527-016-9575-5
Hyperlink
http://link.springer.com/article/10.1007%2Fs10527-016-9575-5

Koudan, E., Bulanova, E., Pereira, F., Parfenov, V., Kasjanovs, V., Hesuani, U., Mironov, V. Spreading of Tissue Spheroids on an Electrospun Polyurethane Matrix. Biomedical Engineering, 2016, Vol.50, No.1, pp.1-4. ISSN 0006-3398. e-ISSN 1573-8256. Available from: doi:10.1007/s10527-016-9575-5

Publication language
English (en)