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Publikācija: Encapsulation of Strontium Ranelate in Poly(Lactic Acid) Matrix

Publication Type Scientific article indexed in SCOPUS or WOS database
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Encapsulation of Strontium Ranelate in Poly(Lactic Acid) Matrix
Field of research 2. Engineering and technology
Sub-field of research 2.5 Materials engineering
Authors Anastasija Smirnova
Dagnija Loča
Līga Stīpniece
Jānis Ločs
Agnese Pūra
Keywords Drug Delivery Systems, Microcapsules, Microspheres, PLA, Strontium Ranelate
Abstract Osteoporosis is a disease characterized with reduced density and quality of bone. Novel treatment strategies have been developed with the aim to inhibit excessive bone resorption and to increase bone formation. Strontium ranelate (SrRan), a novel orally active agent consisting of two atoms of stable strontium and the organic moiety ranelic acid, has proven drug ability to increase not only the bone mass but also mechanical properties. Despite the advantages it has been shown that systemic administration of SrRan can cause such side effects as diarrhea, hypersensitivity and myocardial infarction. Microencapsulation of SrRan could overcome the possible side effects from the systemic drug use as well as to increase its efficiency by local delivery of drug right to the affected bone site. Thus in the current research an attempt was made to prepare and characterize poly (lactic acid)/srontium ranelate microcapsules and to evaluate the drug interaction with the polymer during the microparticle formation.
DOI: 10.4028/www.scientific.net/KEM.721.208
Hyperlink: https://www.scientific.net/KEM.721.208 
Reference Smirnova, A., Loča, D., Stīpniece, L., Ločs, J., Pūra, A. Encapsulation of Strontium Ranelate in Poly(Lactic Acid) Matrix. Key Engineering Materials, 2017, Vol.721, pp.208-212. ISSN 1013-9826. e-ISSN 1662-9795. Available from: doi:10.4028/www.scientific.net/KEM.721.208
Additional information Citation count:
ID 23130