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Publikācija: Cross-linked Dexamethasone Sodium Phosphate Delivery Systems Based on Silver Doped Hydroxyapatite Scaffolds

Publication Type Full-text conference paper published in conference proceedings indexed in SCOPUS or WOS database
Funding for basic activity Unknown
Defending: ,
Publication language English (en)
Title in original language Cross-linked Dexamethasone Sodium Phosphate Delivery Systems Based on Silver Doped Hydroxyapatite Scaffolds
Field of research 2. Engineering and technology
Sub-field of research 2.5 Materials engineering
Research platform None
Authors Arita Dubņika
Dagnija Loča
Līga Bērziņa-Cimdiņa
Keywords Silver hydroxyapatite, scaffolds, dexamethasone, drug delivery.
Abstract One of the most used calcium phosphate implant materials in bone tissue regeneration is synthetic hydroxyapatite, which is similar to mineral phase of bone. By adding antibacterial effect to hydroxyapatite properties and creating controlled drug delivery systems based on this material, it is possible to obtain multifunctional material. Thus, in this study hydroxyapatite was doped with silver up to 1 wt% to provide antibacterial effect and from the obtained material dense and porous scaffolds were prepared. Prepared scaffolds were coated with chitosan and cross-linked with dexamethasone sodium phosphate (DEXA). Scaffolds were characterized and it is shown that linkage between chitosan coating and DEXA on the surface of hydroxyapatite and silver doped hydroxyapatite can ensure the controlled drug release up to 70 h.
DOI: 10.4028/www.scientific.net/KEM.721.192
Hyperlink: https://www.scientific.net/KEM.721.192 
Reference Dubņika, A., Loča, D., Bērziņa-Cimdiņa, L. Cross-linked Dexamethasone Sodium Phosphate Delivery Systems Based on Silver Doped Hydroxyapatite Scaffolds. In: Key Engineering Materials, Latvia, Riga, 3-4 November, 2016. Switzerland: Trans Tech Publications, 2017, pp.192-196. ISSN 1013-9826. e-ISSN 1662-9795. Available from: doi:10.4028/www.scientific.net/KEM.721.192
Additional information Citation count:
  • Scopus  0
ID 23157